Mr. Wogglebug is transported to the city of New York when Professor Knowitall's transportation unit connects to the invention of the scientist Dr. Henry McCarlson there. He is basically like a fish out of water in the big city. He is taken in by Dr. McCarlson and his two little girls and develops friendship with them. He also develops an infatuation with Mindy Mitchell due to her wearing plaid. In the meantime, Dr. McCarlson's rival, Dr. Ben Bertrand has found out about the Wogglebug and poses a threat to his safety.